Innovative mouse model pumps new blood into study of pediatric heart disease

Researchers have created a mouse model of restrictive cardiomyopathy, a disease in which the heart muscle becomes stiff and the heart is unable to properly fill with blood. Their data suggest that the disease results from the accumulation of mutant BAG3 protein, which interferes with the protein quality control system and the machinery for breaking down and recycling damaged proteins, disrupting the heart muscle components.

from Top Health News -- ScienceDaily https://ift.tt/3vPyVTj