Inhibiting nuclear factor kappa B improves heart function in a mouse model of Duchenne muscular dystrophy

Researchers have uncovered an unexpected mechanism that underlies cardiomyopathy (heart failure) in Duchenne muscular dystrophy (DMD). They report that nuclear factor kappa B down-regulates calcium genes, contributing to cardiomyopathy in DMD. Furthermore, data from a mouse model show cardiomyocyte ablation of NF-kappaB rescues cardiac function.

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